From AAV to TAZ

For today’s post, we bring you a “SNiP” or Small News in Pieces! In each SNiP, we will highlight exciting research articles we’ve come across that feature Mirus Bio products… in bite-size pieces.

We all know mitochondria are the powerhouses of the cell. But, have you ever considered how cells make new mitochondria? Interestingly, exercise has been linked to mitochondrial biogenesis.¹ Hwang et al. illuminate the role of transcription factor TAZ in upregulating mitochondrial biogenesis in response to exercise.

So… can we get a dose of TAZ and skip the gym?

Citation

Title: TAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A
Authors: Jun-Ha Hwang, Kyung Min Kim et al.
Journal: Nature Communications, Volume 13, 03 Feb 2022.
DOI: 10.1038/s41467-022-28247-2
Product Usage: TransIT-VirusGEN® Transfection Reagent was used to generate AAV for overexpression and knockdown of the mitochondrial biogenesis transcriptional coactivator TAZ in skeletal muscle.