Enhancing AAV Production: A Novel Transfection System for Cell and Gene Therapy Applications

On Demand Webinar

Enhancing AAV Production: A Novel Transfection System for Cell and Gene Therapy Applications

On Demand Webinar

Learn about the powerful capabilities of the TransIT®-AAViator Transfection System, a turnkey solution designed to significantly improve AAV transfection efficiency. Senior Process Developer at Affinia Therapeutics, Michael White, highlights the system’s scalability and ease of integration, making it ideal for gene therapy developers looking to optimize both upstream processes and overall cost-efficiency.

Michael shares Affinia Therapeutics’ experience with the TransIT-AAViator system, emphasizing its ability to reduce pDNA input requirements while maintaining robust titers across scales. Affinia achieved consistent production results, which led to more efficient manufacturing processes and substantial cost savings.

Discussion highlights include:

  • Affinia’s approach comparing a next-gen transfection system to their current optimized platform (and the subsequent data)
  • How Affinia compared TransIT-AAViator to other reagents and was able to outperform them straight out of the box
  • Methodology used to achieve 3X higher titers and 70% full capsids

Ready to See if TransIT-AAViator is Right for You?

Schedule a meeting to discuss your needs and board your flight to higher titers and percent full capsids.

TransIT®-AAViator Transfection System

A new transfection system tailored specifically for maximal AAV production

TransIT-AAViator Transfection System product image

TransIT®-AAViator Transfection System

A new transfection system tailored specifically for maximal AAV production

TransIT-AAViator Transfection System product image

THE EXPERTS

John Schiel, Ph.D.

Product Manager
Mirus Bio

John brings over a decade of expertise in cellular and molecular biology, specializing in product development and process improvement. He holds a Ph.D. from the University of Colorado Anschutz Medical Campus and a B.S. in Biochemistry from Colorado State University.

As Product Manager at Mirus Bio, John drives innovation in transfection technologies, bridging the gap between research and practical application in AAV production. His leadership roles at Synthego and Artisan Biotechnologies further highlight his contributions to advancing cell therapy and gene therapy development.

John_Schiel
Michael_White_1

Michael White, Ph.D.

Head of Process Development and Manufacturing Innovations
Affinia Therapeutics

Michael is an expert in molecular virology and biotechnology, with extensive experience in viral vector development and process innovation. He holds a Ph.D. in Molecular Virology from Purdue University, an M.S. in Cellular and Molecular Biology from Quinnipiac University, and a B.S. in Biology from the University of Massachusetts Dartmouth.

Currently, Michael serves as Head of New Technologies and Innovation at Affinia Therapeutics, where he leads efforts in advancing viral vector production and evaluating emerging technologies. His previous roles include leadership positions at Ring Therapeutics and MedImmune, focusing on vector innovation and bioprocess development.

Ready to See if TransIT-AAViator is Right for You?

Schedule a meeting to discuss your needs and board your flight to higher titers and percent full capsids.