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The TransMission: SNiP

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Last Updated: August 8, 2022

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Electroporation IconToday we SNiP an 'electrifying' article on T cell electroporation featuring Ingenio® Electroporation Solution. In each SNiP (Small News in Pieces), we highlight exciting research articles we've come across that feature Mirus Bio products... in bite-size pieces.

Staphylococcal enterotoxins, which are mostly secreted from the bacterium Staphylococcus aureus, are linked to a host of diseases including food poisoning, toxic shock syndrome and cutaneous T cell lymphoma.1,2 How these bacterial 'superantigens' contribute to exacerbating cutaneous T cell lymphoma is the question Willerslev-Olsen et al. examine in this article. Specifically, they highlight the interplay of these enterotoxins and the activation of oncogenic microRNA miR-155 in malignant T cells.

Though a clinical trial (NCT03713320) of a miR-155 inhibitor was recently terminated, miR-155 remains a promising drug target.3

 

Title: Staphylococcus aureus Induces Signal Transducer and Activator of Transcription 5-Dependent miR-155 Expression in Cutaneous T-Cell Lymphoma

Authors: Andreas Willerslev-Olsen, Lise Mette Rahbek Gjerdrum et al.
Journal: Journal of Investigative Dermatology, Volume 141, 13 Apr 2021.
DOI: 10.1016/j.jid.2021.01.038

Product Usage: T cell lines (SeAx and MyLa1850) and PBMCs were resuspended in Ingenio® Electroporation Solution and electroporated with siRNA to study miR-155 activation pathways.

Read about other cell types and nucleic acids that have been electroporated successfully with Ingenio® Electroporation Solution by visiting our Citations Database.

 

References

  1. Pinchuk, I. V., et al., Toxins (2010).
    DOI: 10.3390/toxins2082177
  2. van Kester, M. S., et al., Molecular Oncology (2011).
    DOI: 10.1016/j.molonc.2011.02.003
  3. ClinicialTrials.gov, SOLAR: Efficacy and Safety of Cobomarsen (MRG-106) vs. Active Comparator in Subjects With Mycosis Fungoides (SOLAR). Identifier: NCT03713320.

The TransMission

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