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GMP Transfection for AAV Production

TransIT-VirusGEN® GMP Transfection Reagent and Kits

TransIT-VirusGEN®

Nucleic Acid Delivery

  • Achieve higher titers and percent full AAV capsids
  • >50% savings on a cost per dose basis vs. the leading competitor
  • Universally platformable across all AAV serotypes
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VirusGEN GMP Bottle

The Highest Quality Grade for Cell & Gene Therapy

VirusGEN® is a proven transfection reagent combining industry-leading yield performance with real world economic
advantages by delivering a reduced cost per dose — all supported by comprehensive expertise for cell and gene therapy.

VirusGEN® specifications support virus production fit-for-purpose requirements.

Comparison of VirusGEN Transfection Reagents from R&D to Clinical Trial and Commercial Manufacturing

 

Designed to be Biomimetic for Optimized Performance

Illustration of Mirus' Core Technology           

What makes VirusGEN® unique?

  • Mirus proprietary lipid and polymer technology
  • Forms lipopolyplex with DNA (or nucleic acid)
  • Biomimetic behavior increases transfection efficiency

What benefit does this bring?

  • Higher titers vs. PEI (2-10x) and higher percent full AAV capsids
  • >50% savings on a cost per dose basis vs. the leading competitor
  • Universally platformable for LV and across all AAV serotypes
 

Figures and Data

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VirusGEN® Outperforms Competitor Reagents in Various AAV Serotypes

VirusGEN Outperforms Competitor Reagents in Various AAV Serotypes
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VirusGEN® Percent Full Titer Consistently Outperforms Competitors

VirusGEN Percent Full Titer Consistently Outperforms Competitors
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Higher Titers Deliver Significant Cost Per Dose Savings

Higher Titers Deliver Significant Cost Per Dose Savings
AAV9 200L bioreactor cost simulation.
Contact Technical Support for complete experimental details: techsupport@mirusbio.com

Documentation

Specifications

Storage Conditions:
VirusGEN® GMP AAV Transfection Kit: Multiple storage conditions - see individual bottles for specific recommendations
TransIT-VirusGEN® GMP Transfection Reagent: Store at -10 to -30°C

Product Guarantee:
All Configurations: Refer to Certificate of Analysis for Retest Date

Usage Statement:
All Configurations: For Research Use and Further Manufacturing; Not for Administration into Humans.

Animal Origin Statement:
All Configurations: This product is animal origin free.

Technical Product Literature

Full Protocols

TransIT-VirusGEN® GMP Protocol
VirusGEN® GMP AAV Transfection Kit Protocol

SDS

TransIT-VirusGEN® GMP SDS
VirusGEN® GMP AAV Transfection Kit SDS


Additional Resources

Frequently Asked Questions

VirusGEN® GMP AAV Transfection Kit FAQ
TransIT-VirusGEN® GMP Transfection Reagent FAQ

Reagent Agent®Tips from the BenchEmail Technical Support

COO Lookup

Download Certificate of Origin

Directly from Our Customers

 

Podcast thumbnail                Listen to the first-hand account of how Mirus helped researchers from St. Jude overcome the challenges with viral vector optimization to produce ground-breaking gene therapy for hemophilia. Go to the podcast >> 

Testimonials

 
Mirus sent me samples of TransIT-VirusGEN® to test with 293T cells to generate lentivirus. It outperforms the transfection reagent I was using before. The protocol is really simple, and the transfections are robust. I’m getting great virus production.
Dr. Steve Williams
Xyphos Inc.