Applications | GMP Transfection for AAV Production

TransIT-VirusGEN® GMP Transfection Reagents and Kits

Nucleic Acid Delivery

  • Achieve higher titers and percent full AAV capsids
  • >50% savings on a cost per dose basis vs. the leading competitor
  • Universally platformable across all AAV serotypes
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ISO 13485:2016 Certified

Completion of this comprehensive certification process underscores the quality of the processes used to support the company’s GMP product portfolio

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The Highest Quality Grade for Cell & Gene Therapy

VirusGEN® is a proven transfection reagent combining industry-leading yield performance with real world economic
advantages by delivering a reduced cost per dose — all supported by comprehensive expertise for cell and gene therapy.

VirusGEN® specifications support virus production fit-for-purpose requirements.

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Designed to be Biomimetic for Optimized Performance

What makes VirusGEN® unique?

  • Mirus proprietary lipid and polymer technology
  • Forms lipopolyplex with DNA (or nucleic acid)
  • Biomimetic behavior increases transfection efficiency

 

What benefit does this bring?

  • Higher titers vs. PEI (2-10x) and higher percent full AAV capsids

 

VirusGEN Outperforms Competitor Reagents in Various AAV Serotypes
VirusGEN AAV Transfection Kit Competitor comparison Data

VirusGEN Percent Full Titer Consistently Outperforms CompetitorsVirusGEN-AAV Transfection Kit AAV percent full titer Data

Higher Titers Deliver Significant Cost Per Dose Savings

VirusGEN AAV Transfection Kit Cost per dose comparison Data

Documentation

Specifications

Storage Conditions:

VirusGEN® GMP AAV Transfection Kit: Multiple storage conditions – see individual bottles for specific recommendations
TransIT-VirusGEN® GMP Transfection Reagent: Store at -10 to -30°C

Product Guarantee:

All Configurations: Refer to Certificate of Analysis for Retest Date

Usage Statement:

All Configurations: For Research Use and Further Manufacturing; Not for Administration into Humans.

Animal Origin Statement:

All Configurations: This product is animal origin free.

 

Technical Product Literature

Full Protocols

TransIT-VirusGEN® GMP Protocol (PDF)
VirusGEN® GMP AAV Transfection Kit Protocol (PDF)

SDS

TransIT-VirusGEN® GMP SDS (PDF)
VirusGEN® GMP AAV Transfection Kit SDS (PDF)

Directly From Our Customers

Listen to the first-hand account of how Mirus helped researchers from St. Jude overcome the challenges with viral vector optimization to produce ground-breaking gene therapy for hemophilia. Go to the podcast >> 

"Mirus sent me samples of TransIT-VirusGEN® to test with 293T cells to generate lentivirus. It outperforms the transfection reagent I was using before. The protocol is really simple, and the transfections are robust. I’m getting great virus production."
Dr. Steve Williams
Xyphos Inc.