Label IT® RNAi Delivery Controls
Fluorescently labeled RNAi duplexes ideal for in vitro or in vivo tracking
| Product No. | Quantity | Price | Add to |
| Cy™3 |
| MIR 7900 | 10 µg (0.75 nmol) | $113.00 |
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| MIR 7901 | 100 µg (7.5 nmol) | $558.00 |
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| Fluorescein |
| MIR 7902 | 10 µg (0.75 nmol) | $85.00 |
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| MIR 7903 | 100 µg (7.5 nmol) | $419.00 |
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Resources
Protocol
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- Sensitive—Easily visualize transfected cells and assess delivery efficiency using fluorescent microscopy.
- Inert—Not known to target any mammalian genes or cause off-target effects.
- Compatible—Suitable for co-delivery experiments with functional siRNA.
- Ease of Use—Supplied as a ready to use 10 µM stock solution with a 10X RNAi Dilution Buffer.
Data
 Figure 1A |
 Figure 1B |
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The Label IT® RNAi Delivery Controls Allow Quick Assessment of Delivery Efficiency For In Vitro Applications.
Figure 1A. HeLa cells were transfected in serum-containing media with the Label IT® Cy™3 RNAi Delivery Control (red) using the TransIT®-siQUEST™ Transfection Reagent. Twenty-four hours post-transfection, the cells were fixed, then counterstained to locate the nuclei (blue) and the actin (green).
Figure 1B. HeLa cells were transfected in serum-containing media with the Label IT® Fluorescein RNAi Delivery Control (green) using the TransIT-TKO® Transfection Reagent. Twenty-four hours post-transfection, the cells were fixed, then counterstained to locate the nuclei (blue) and the actin (red). |
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Figure 2. Visualization of the Label IT® Cy™3 RNAi Delivery Control in Liver Sections Following Tail Vein Injection. TransIT®-QR Hydrodynamic Delivery Solution was used to deliver 25 µg of Label IT® Cy™3 RNAi Delivery Control (red) to a mouse using hydrodynamic delivery via the tail vein. Forty-five minutes post-injection the liver was harvested. Sections were processed to stain the nuclei (blue) and to stain the actin (green). |
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Notice: In vivo hydrodynamic delivery of non-viral nucleic acids is covered by patents and patent applications of Mirus Bio Corporation, including U.S. Patent 6,627,616 and related filings worldwide. Purchase of this product does not provide a license to this delivery technology, which is required for all research and commercial uses by for-profit entities. To inquire about a license, please contact Mirus Bio.
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