Licensing Opportunity
Genetic Immunization to Produce Ab
In Vivo Gene Transfer
Genetic immunization is an elegant methodology to generate antibodies directed against antigens for which the coding sequence is known. By introducing an expression vector into the animal host, the antigen is synthesized in situ. This provides a properly processed antigen, while avoiding the need for expensive protein isolation or peptide synthesis. Mirus Bio Corporation has invented a technology platform for efficient genetic immunization which involves the intravenous injection of plasmid DNA (pDNA) into either a tail vein or limb vein under elevated pressure. This robust methodology results in rapid, high-titer antibody responses directed against the expressed antigen. Compared to existing approaches, this technology offers significant advantages: no specialized equipment requirement, easily applied in small and large research animals, and effective, rapid antibody induction.
Bates, MK, et. al.
Genetic Immunization for Antibody Generation in Research Animals by Intravenous Delivery of Plasmid DNA. BioTechniques, Vol. 40, No. 2, February 2006.
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